GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9902453 | 1 | rs28664971 | chr17:28437410 | EFCAB5 | chr17:28256874-28435469:+ | 0.33 | 4.51 | 1.84E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs1875620 | 1 | rs28667788 | chr9:91560954 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs9815354 | 1 | rs28702390 | chr3:41889920 | ULK4 | chr3:41288091-42003660:- | 0.96 | 9.51 | 1.88E-15 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs28733681 | chr3:41863444 | ULK4 | chr3:41288091-42003660:- | 1 | 10.81 | 3.16E-18 | Diastolic blood pressure |
| THYM | cis | rs7223966 | 1 | rs2874121 | chr17:61731024 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.41 | 2.72E-5 | Body mass index |
| THYM | cis | rs9815354 | 1 | rs28755797 | chr3:41774446 | ULK4 | chr3:41288091-42003660:- | 0.98 | 9.58 | 1.33E-15 | Diastolic blood pressure |
| THYM | cis | rs9876781 | 1 | rs28824259 | chr3:48425675 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.38 | 3.02E-5 | Longevity |
| THYM | cis | rs1875620 | 1 | rs28852385 | chr9:91559244 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs9876781 | 1 | rs2885510 | chr3:48418226 | TREX1 | chr3:48501186-48509043:+ | 0.28 | 4.49 | 2.0E-5 | Longevity |
| THYM | cis | rs10935120 | 1 | rs2887797 | chr3:134202506 | ANAPC13 | chr3:134196547-134204865:- | 0.56 | 7.74 | 1.08E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs2887797 | chr3:134202506 | CEP63 | chr3:134204575-134293852:+ | 0.39 | 5.72 | 1.23E-7 | Height |
| THYM | cis | rs9309473 | 1 | rs2901438 | chr2:73665656 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.7 | 8.77E-6 | Metabolite levels |
| THYM | cis | rs2294008 | 1 | rs2920283 | chr8:143757037 | PSCA | chr8:143761875-143764142:+ | 0.44 | 4.23 | 5.48E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs2294008 | 1 | rs2920292 | chr8:143765699 | PSCA | chr8:143761875-143764142:+ | 0.43 | 4.3 | 4.13E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs2294008 | 1 | rs2920293 | chr8:143765414 | PSCA | chr8:143761875-143764142:+ | 0.44 | 4.3 | 4.12E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |